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NR Supreme

NR Supreme

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We are thrilled to announce the release of our newest product NR Supreme, the first encapsulated NR product, on the practitioner-only market.

Each capsule of NR Supreme delivers 300 mg of Nicotinamide Riboside and assists with NAD+ production and enhanced NAD+ levels in the body.

Allergen Information: No added Soy, Gluten, Dairy or Nuts. Vegan friendly

Background

Nicotinamide riboside (NR) is one of the most well-studied nicotinamide adenine dinucleotide (NAD+) precursors due to its capacity to elevate NAD+ levels in the body

Mechanism of Action  Nicotinamide (NAM) is required for the synthesis of NAD+, an essential coenzyme involved in several metabolic pathways. In fact, an estimated 200 enzymes – including dehydrogenases – require NAD and NADP as coenzymes. As an electron carrier, NAD+ is necessary for oxidative reactions that occur in the cytosol and mitochondria. Due to its capacity to extract energy from substrates, NAD+ is fundamental to cellular health. NAD+ is also required for carbohydrate oxidation during adenosine triphosphate (ATP) production.

Pharmacokinetics Absorption: Nicotinamide is absorbed predominantly in the small intestine via facilitated diffusion. Once in the bloodstream, nicotinamide moves across cell membranes via passive diffusion. Metabolism to NAD+: NR acts as a precursor in producing NAD+ via two pathways:

1 - The NRK1/2 Pathway NR is phosphorylated to nicotinamide mononucleotide (NMN) by the enzyme NR kinase Nrk1. The resulting MNM is then converted to NAD+ by NMN adenylyltransferase.

2- The salvage pathway NR, Nicotinic acid (NA) or NAM is converted to NMN under the influence of the enzyme nicotinamide phosphoribosyltransferase (NAMPT). NMN is then converted to NAD+ by nicotinamide mononucleotide adenylyltransferase (NMNAT aka NMN transferase).

NR has the ability to maintain intracellular levels of NAD+ in the body.4 In the first human clinical trial conducted with NR, results found that blood NAD+ levels can increase up

Chronic pain is complex in regards to its’ aetiology, pathophysiology and mechanistic classification, and consequently, its effective therapeutic management/treatment without the occurrence of to 2.7 fold with a single oral dose of NR. A randomised, double-blind, placebo-controlled trial consisting of 113 people receiving NR in combination with pterostilbene (NRPT) found that the group receiving NRPT at 250mg per day had significantly increased NAD+ levels to 40% over baseline. side effects is an ongoing clinical challenge.


Elimination: The enzyme glycohydrolase transforms NAD into adenosine diphosphate-ribose and nicotinamide. The resulting nicotinamide is then released from cells for processing by the liver. Nicotinamide undergoes methylation and oxidation in the liver – its metabolites are then excreted in the urine. Much of the free nicotinamide is reabsorbed into the body via glomerular filtrate

Patient Benefits

  •  Increases NAD+ status and replenishes the body’s NAD+ pool
  • Provides nutritional support for NAD+ replenishment which can:
    • Support energy production
    • Support healthy aging
    • Provide antioxidant support

Directions for Use:

Adults: Take one capsule daily or as directed by your health professional.

Allergen Information

  • No Added: Soy, Dairy, Nuts, Eggs, Yeast, Sesame.
  • Free From: Colours, Flavours, Benzoates, Sulfites, Sorbates.
  • Vegan Friendly

Warnings

  • Not to be taken by children under 12 years old.
  • Not recommended for use during pregnancy or lactation.
  • Vitamin supplements should not replace a balanced diet.
  • Contains ribose which is a sugar.